Authentic Biochemistry

Far from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and  tumor microenvironments.  Dr Dan Guerra 30 June 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cytokine mediated hyper-immune response. Published 29 June 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this  session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example,  the physiological role of plasminogen activator inhibitor 1 (PAI-1) involves control over fibrinolysis  which is an essential  hemostatic mechanism for regulating the dissolution of fibrin clots associated with airway passage remodeling  systemic wound repair, and the inflammatory response as linked to cytokine mediated immune responses and circulating t-PA mediated cardiovascular function. Dr Guerra also mentioned that he has established a PATREON site:   https://www.patreon.com/user?u=37615512&fan_landing=true&fbclid=IwAR0L8ADIhtIgZM_WtkJejz_x-3hAdzr39mrvoZxdAu6glm9zkAG5L4NnhCo Lease strongly consider recombining with the Patreon link as a means to provide monetary donations to the Authentic Biochemistry Podcast and YouTube lecture series plus the VerEvMed Facebook postings that include Authentic Biochemistry "Minutes" and some

In this Lecture I define and then implement  a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr. Dan Guerra apprehends several research publications going back to 2012  and proceeding through 2019 in a synthesis of oppostional logic and the published scientific evidence to explain the mediation of metabolic zonation, transcriptional control, and bioenergetcs using PEDF to mitigate cancer progression.   --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

A brief concluding lecture on   the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring.  --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra lays out the prodromal manifestations of metabolic syndrome and insulin resitance that can lead to Type 2 diabetes in the obese sedentary aging population. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra reminds his audience that obesity is the global health pandemic of a generation and that it leads to multiple high mortality diseases associated with a corruption in lipid metabolism, both innate and acquired immunity and associated cancer and cardiovascular disorders. Because obesity sets as a precondition and continued distress to human health and well-being, the predisposition to a constellation of diseases both infectious and non-infectious is obtained. Recorded and produced on 25 May 2020 by Dr Daniel J. Guerra --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra provides the basic detail necessary to prepare one for our future examination of the current peer-reviewed literature involving hormonal control over health , infection and inflammation via the immune system. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra discusses hormonal ontology via receptor -binding mechanisms plus the cascade of the hypothalamic-pituitary axis.   --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra gives a fast paced knowledge-laden series of lectures on the medical physiological and biochemical features of human hormonal signaling. Lecture I Introduction and Classification. Published on line 04 May 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra  opens up the refereed published scientific literature to provide verified evidence associated with the arcuate nucleus of the hypothalamic arc leading to hormonal  control over nutrition and the immune system. Published 28 April 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Patho-Biochemical Pathways in CNS-Endocrine Organs with a special emphasis on sphingomyelin phosphodiesterases in the HPA axis of the CNS and Beta hemolysins as virulence factors from the human bacterial pathogen, Staphylococcus  aureus. Dr Daniel J Guerra published on 27 April 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

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Dr Guerra delivers his third informed discussion of Membrane lipid raft biology and the role of Sphingolipids in mediating an immune response that results in massive tissue damage and poor disease outcome. Published 11 April 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this audio lecture presentation, Dr Guerra gives an aggregated explanation for the association of subcellular biochemical metabolism of sphingolipids via the target of Cationic Amphipathic Drugs such as SSRI's in altering cell fate from programmed cell death to tissue preserving autophagy. Published 11 April 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Dr Guerra uses the Dialectical Method via the Logical Square of Opposition combined with an analysis of the current biomedical evidence associated with the COVID 19 corona virus  to obtain validated conclusions. 23 March 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this third segment on the grounding of Natural Science and the world View it advances,  Dr Dan Guerra introduces the endojective perspective for space-time and the foundation of knowledge toward the representation of phenomena as pattern recognition from a possibilistic metaphysical landscape via freely chosen inductive reasoning in an ultimately uncertain universe. Published 20 March 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

In this second philosophical segment, Dr. Guerra introduces space-time as a physical manifestation of the synthetic a priori of Phenomenological Metaphysics as he draws inferences from pre-Socratic concepts of vortices and co-mingles these ideas with Clerk Maxwell's explanation of the electromagnetic theory and quantifiable resolution for the velocity of light. Published on the IDES of March 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message