Sinopsis
You have wisely landed upon Authentic Biochemistry, with Dr Daniel J Guerra, where published research and clinical science is interrogated.
Episodios
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![Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020.]()
Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020.
01/09/2020 Duración: 25minDr Guerra builds the foundation for transcription factor and epigenetic regulation of Treg cell differentiation in counterbalance to ILC's and T effector lymphocyte populations. Published 01 September 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![T lymphocyte and MVA pathway cross-talk in Breast Cancer, Lymphomas, Leukemias, CVD and aging. 24 August 2020]()
T lymphocyte and MVA pathway cross-talk in Breast Cancer, Lymphomas, Leukemias, CVD and aging. 24 August 2020
24/08/2020 Duración: 27minDr. Daniel Guerra recombines the discussions of pharmacotherapeutic inhibition of prenylation in T cell activation and the failure of the NF-Kappa B pathway in estrogen receptor associated breast cancer and the lymphoproliferative lymphomas and leukemias with aging and neurodegeneration. PUblished 24 August 2020. Please join our Patreon and contribute to Authentic Biochemistry today! --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![The Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan Guerra]()
The Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan Guerra
19/08/2020 Duración: 28minDr Guerra discusses the induction of transcription factor SREBP in activated T lymphocytes and the regulation of cellular translocation from the ER to the Golgi to the nucleus for the induction of prenyl and acyl lipogenesis, Published 18 August 2020 by Dr Daniel J. Guerra. Review of: Front. Pharmacol., 17 March 2020. https://doi.org/10.3389/fphar.2020.00265 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra lectures about Chronic Genomic Instability as a means to an end called senescence. Published 06 August 2020.]()
Dr Guerra lectures about Chronic Genomic Instability as a means to an end called senescence. Published 06 August 2020.
07/08/2020 Duración: 28minIn this segment I discuss the phenomenon of DNA and genomic instability and the DNA repair systems implemented as mechanisms to drive cellular longevity . 06 August 2020 . --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra discusses canonical Programmed Cell Death. Published 05 August 2020]()
Dr Guerra discusses canonical Programmed Cell Death. Published 05 August 2020
05/08/2020 Duración: 29minProgrammed Cell Death is a classical cell fate that occurs during embryonic development, tissue repair and both leucocyte and lymphocyte turnover. Various subforms of apoptosis ( classical, necroptosis and ferroptosis) are also involved during infection, genotoxicity, oncogenesis and aging. Published By Dr Guerra 05 August 2020. Subscribe to the podcast! Contribute on Patreon! --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![The Aging biochemical landscape as associated with chromatin organization and the alteration of cell cycle dynamics leading to the Senescence Associated Secretory Phenotype]()
The Aging biochemical landscape as associated with chromatin organization and the alteration of cell cycle dynamics leading to the Senescence Associated Secretory Phenotype
04/08/2020 Duración: 29minDr Guerra discusses the cancer marker gene mKI67 and its turnover linked to predisposition to euchromatin formation and the progression toward a senescent phenotype. Published 04 August 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra discusses how Isoprenoid metabolism is linked to T cell activation via glycolysis and glutaminolysis. 02 August 2020]()
Dr Guerra discusses how Isoprenoid metabolism is linked to T cell activation via glycolysis and glutaminolysis. 02 August 2020
02/08/2020 Duración: 27minThe mevalonic acid biosynthetic pathway maintains canonical cell activation triggers that link intermediary metabolism to T lymphocyte differentiation. 02 August 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020]()
Dr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020
01/08/2020 Duración: 29minThe master regulator of protein translation, mTORC, is itself regulated by the stress-induced AMPK pathway. Rapamycin and semi-selective drugs regulating AMPK may reduce glioblastoma progression and this observation helps to advance a theory for healthy longevity that requires a reduction in anabolism. By Dr Daniel J. Guerra. Published 01 August 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra discusses aging associated oxidative phosphorylation, gluconeogenesis, NAD+ sirtuin activity and telomerase. 30 July 2020]()
Dr Guerra discusses aging associated oxidative phosphorylation, gluconeogenesis, NAD+ sirtuin activity and telomerase. 30 July 2020
30/07/2020 Duración: 29minIn this lecture I gather some of the notable molecular components of age-related decline and the contrarion opposition imposed by cell proliferation. Published 30 July 2020. DJGPhD. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![The Categorical Logic of Aging Systems as Influenced by Nutrition and the Introduction of Pharmacotherapeutics that Target Disease. Lecture VI. Published 27 July 2020.]()
The Categorical Logic of Aging Systems as Influenced by Nutrition and the Introduction of Pharmacotherapeutics that Target Disease. Lecture VI. Published 27 July 2020.
28/07/2020 Duración: 29minDr Dan Guerra examines nutritional restriction and exercise in combination with anti-diabetic drugs to impact the aging process. Published 27 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020.]()
The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020.
26/07/2020 Duración: 29minDr Guerra explains chain initiation, propagation and termination during lipid oxidation and the REDOX reactions of the electron transport chain as a lead in to enzymatic oxidations and the plasticity of immune linked senescence. 26 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Reactive oxygen is generated in biological systems leading to a physiological transit to senescence. Published 24 July 2020]()
Reactive oxygen is generated in biological systems leading to a physiological transit to senescence. Published 24 July 2020
25/07/2020 Duración: 29minDr Guerra lays out the reduction of molecular oxygen to water and the accumulation of intermediate free radical oxygen species that are reduced via enzymatic activity and anti=oxidants. Aging is related to the auto-oxidation of nucleic acids, protein and significantly, membrane unsaturated molecular species of lipids. 24 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![The oncogenic intermediary metabolic corruption as contrarion ontology to aging. Published 24 July 2020.]()
The oncogenic intermediary metabolic corruption as contrarion ontology to aging. Published 24 July 2020.
24/07/2020 Duración: 29minDr Guerra explains how mutations in the glycolytic enzyme, pyruvate kinase, may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Biochemical/Physiological Paradigms of Aging and Tumor Metabolism: the classical Warburg Aerobic Glycolysis and Krebs Cycle Corruption. 21 July 2020.]()
Biochemical/Physiological Paradigms of Aging and Tumor Metabolism: the classical Warburg Aerobic Glycolysis and Krebs Cycle Corruption. 21 July 2020.
21/07/2020 Duración: 29minDr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra starts a series on the biochemistry and physiology of human aging and the ontology of sequential phenomenon in living systems. 19 July 2020.]()
Dr Guerra starts a series on the biochemistry and physiology of human aging and the ontology of sequential phenomenon in living systems. 19 July 2020.
19/07/2020 Duración: 29minToday I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One. Also please consider contributing to Authentic Biochemistry by becoming a patron on Patreon. I need your support! https://podbay.fm/podcast/1454408625 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus .]()
Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus .
12/07/2020 Duración: 28minThe synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Neutrophil elastase-mediated pulmonary disease including Cystic Fibrosis, RDS, COPD and viral pneumonia 10 July 2020]()
Neutrophil elastase-mediated pulmonary disease including Cystic Fibrosis, RDS, COPD and viral pneumonia 10 July 2020
10/07/2020 Duración: 28minAirway passage disease has been well characterized in cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and viral pneumonia as that ascribed to the coronavirus 19. Published 10 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![A Narrative on the Nature of Belief as Universal within Knowledge yet Regularly Discounted in the Scientific World View. 09 July 2020]()
A Narrative on the Nature of Belief as Universal within Knowledge yet Regularly Discounted in the Scientific World View. 09 July 2020
09/07/2020 Duración: 27minDr Guerra presents his existential view on the purposive avoidance in science to admit the significance of belief in the knowledge paradigm. 09 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Serpins and the Neutrophil Extracellular Traps in Respiratory Distress and the Coronavirus. 08 July 2020]()
Serpins and the Neutrophil Extracellular Traps in Respiratory Distress and the Coronavirus. 08 July 2020
08/07/2020 Duración: 28minDr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
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![Dr Guerra examines proteases and protease inhibitors in ovarian and hepatocellular cancers and their pathobiochemical mechanisms. 03 July 2020.]()
Dr Guerra examines proteases and protease inhibitors in ovarian and hepatocellular cancers and their pathobiochemical mechanisms. 03 July 2020.
03/07/2020 Duración: 28minDr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Associated Degradation pathway and Unfolded Protein Response to induce autophagy-linked Hepatocellular Carcinoma. Finally, a mechanistic step-wise summary of the serine protease catalytic triad is presented. Published 03 July 2020. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message
