Authentic Biochemistry

Scientific Reports volume 9, Article number: 1220 (2019) Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12 Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221  Pharmacological reports 2005, vol. 57, no6, pp. 811-817 Brain Res Bull, December 11, 2006; 71(1-3): 279-86. Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997) Scientific Reports volume 7, Article number: 13763 (2017) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Brain Behav Immun. 2019 Oct;81:41-51 Neuroimmunomodulation 2002/2003;10:101-121 Front. Neurol., 23 January 2018 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling. TLR  interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's. J Neuroinflammation. 2014 Sep 20;11:166 Brain Behav Immun. 2019 Oct;81:41-51 J Mol Neurosci. 2021 Mar 9 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Pathogens, and abiotic ischaemic damage manifest a constellation of  molecular interactions triggering pattern recognition receptors such as TLR's, with canonical protein binding domains that signal through intracellular cascades such as activating  Ca2+ signaling; eo ipso obtaining potent hyperimmune inflammation,  providing  event ontological foundation and episodic contribution to the aging morbidity in human decline and mortality. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Oncotarget. 2016 Jan 26; 7(4): 4195–4209 Nature Reviews Immunology volume 6, pages644–658(2006) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

The removal of damaged neurons and associated synaptic connections with the simultaneous repair of other neuronal circuits is a mechanism for the sculpting of the brain network and thus a means by which the highly innervated and connected prefrontal cortex can receive and respond to neurotransmission from the limbic system. Reference: Genes (Basel). 2019 Mar; 10(3): 249 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Authentic Biochemistry Podcast 27 April 2021 References Clin Diagn Lab Immunol. 2003 Jan;10(1):13-8 J Exp Med (2012) 209 (1): 187–199. Cell Reports 2020. V 30, (Issue 5) :1585-1597.e6 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

References Experimental & Molecular Medicine volume51, Article number: 80 (2019) Am J Nephrol.2017;46(5):371-379 EMBO Rep . 2003 Aug;4(8):774-80 J Biol Chem. 2020 Jul 3;295(27):9052-9060 Mol Immunol. 2017Aug;88:125-134 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

As an hypothetico-deduction,  Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity. In conjunction with a neutral sphingomyelinase and the subsequent synthesis of diacylglycerol thence promoting activation of a PKC-Zeta, T cell receptor translocation and activation are obtained.  Prior RAG mediated recombination events in CNS-resident lymphocytes, associated microglia and neurons can lead to recombination event epigenomic ontologies that either promote or curtail a resident hyperimmune response   leading to classical neurodegenerative diseases of the elderly. References: J. Biol. Chem. 1998;273:14550-14559 Frontiers in Immunology.2014. 5:100 Front Cell Dev Biol. 2019; 7: 226. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Single-nucleotide polymorphisms and  copy-number variations (CNV’s)  result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in  the accumulation of chromosomal variation. Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene proteins RAG1 & RAG2 that are canonically linked to V(D)J recombination of the T cell receptor and the B cell immunoglobulins. FEBS J. 2017 Jun; 284(11): 1590–1605. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Neuroinflammatory mediators play a critical role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. These processes occur throughout life and involve the immune system, biochemical pathways, cellular turnover and alteration of gene expression. Signal transduction cascades allow for genome editing to epigenomic mediation of metabolic event ontologies. Aging is a process whereby these processes lose specificity and valence, increasingly functioning without appropriate fine control leading to the potential for chronic and more rarely, acute disease states that ultimately result in mortality --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

An Introduction to the theory of immunoepigenetic tailoring of human instanence. Dr. Guerra Authentic Biochemistry Podcast Studios --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

J Immunol August 1, 2017, 199 (3) 874-884 Ann Rev Cell Dev Biol 2018. 34:111-136 Blood. 2016 Apr 14;127(15):1930-9 J BiolChem. 2017 Aug 25; 292(34): 14292–14307 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

What is involved to make a sound decision? Biochemistry is a scientific discipline; one that examines and interprets the foundational structures and functions of living systems. As with any judgment, as there are reasons for believing, there are also reasons for disbelieving, and the freely willed decision to choose which, should involve the discovery of truths to use as exemplars for seeking coherence and foundation to the premises that necessarily and sufficiently support the better argument for that decision Listen to my lecture to learn the details of this unfolding discussion that recombines epistemology with metaphysics as re-purposed to find Authentic Biochemistry. DJGPhD 31 March 2021 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Annual Review of Cell and Developmental Biology Vol. 34:111-136 Journal of Neuroscience 23 October 2019, 39 (43) 8576-8583 Archivum Immunologiae et Therapiae Experimentalis 2013 Apr;61(2):119-25. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

 In this foundational lipid absorption lecture,  Dr. Guerra address the roles of apo- lipoproteins, triacylglycerol and cholesteryl esters with membrane associated caveolae transport in adipocytes, endothelia and skeletal muscle. An Authentic Biochemistry Podcast Production. 25 March 2021. --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

Electron transport and the anapleurotics of intermediary metabolism. Dr. Daniel J. Guerra Authentic Biochemistry Studios 21.3.21 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

•Impaired immunological responsiveness is common in the elderly •The immunological competence of an individual is determined by the presence of mature lymphocytes formed in primary lymphoid organs, and secondary lymphoid tissues such as the liver, lung and GI tract. •Immunological equilibrium requires steady lymphocyte output, and controlled expansion •Thymic and lymph-node stromal microenvironments thus represent key elements in the development of the adaptive immune system. Consequently, impairment of the lymphoid microenvironment will ultimately lead to insufficient primary and secondary immune responses or to the decline of thymic selection, manifesting in immune senescence accompanied by late-onset autoimmune disorders, often observed in elderly. •Self-tolerant cytotoxic and helper T-lymphocytes, the crucial regulator cells in adaptive immune responses, develop in the specialized epithelial network of the thymus. The thymus, however, gradually loses its capacity to support lymphopoiesis in an involution

•Cytokines regulate the intensity and duration of the immune response, and  they can act as growth factors or stimulants or even inhibitors of T cell amplification and differentiation. •Cytokines are glycoproteins that are synthesized through a dolichol PP mediated pathway in the ER and are thus dependent upon prenyl lipid metabolism Endoplasmic reticulum localized ADPGK serves glycoprotein synthesis and also functions to control glycolytic vs. aerobic bioenergetic intermediary metabolic agency in lymphocytes. Scientific Reports volume 9, Article number: 14248 (2019) --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message

1. Glucokinase- GK is in the neuron 2.Control over glycolysis via GK mediates neural transmission 3.  Neuronal GK further functions on  the appetite/satiety axis thus partially regulating the HPA axis 4. Aging and immune associated dysfunction of these glycolytic systems are associated with neurodegeneration and the loss of neuronal action potential mediated learning, memory, and mood. Therefore, metabolic control over the severity of chronological age and the immunosenescence of the CNS can be exacerbated by visceral obesity thus linking CNS decline to the major causes of morbidity and mortality in the aging human population. Curr Opin Lipidol. 2015 Apr; 26(2): 88–95 Am J Physiol Endocrinol Metab. 2016 Jul 1; 311(1): E42–E55 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message