Journal Of Investigative Dermatology

26 April 2013: In this podcast, Dr. Robert Dellavalle speaks with Dr. Victoria Werth about increased mucin in patients with dermatomyositis and how this relates to increased accumulation of a sugar chondroitin sulfate, CD44 Variant 7 and Osteopontin. This clinical finding has been modeled in in vitro experiments of stretched fibroblasts and provides an example of how the immune system can trigger a chronic inflammatory response in the skin.