Dr. Howard Smith Oncall

Producing Stronger Vaccines Faster By Harnessing Bacteria

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Sinopsis

Vidcast:  https://www.instagram.com/p/DUmSfKQDoQz/Genetically modifying bacteria using AI-refined DNA leads to production of vaccines with 8-fold higher immunogenicity in a time-frame even 5 times shorter than even the speedy mRNA technology. Microbiologists at the University of Virginia and Duke University now report this proof-of-concept in the journal Vaccines.This novel approach utilizes inactivated bacteria programmed with synthetic DNA instructions to produce new, highly effective vaccine antigens in about 3 weeks. The DNA design is guided by AI protein-structure modeling. The resultant vaccines are stable at refrigerator temperatures. They are inexpensive to produce costing less than $1/dose. In contrast, mRNA vaccines require more complex manufacturing and ultra-cold storage. They require about 3 months or more to go from design to a test-ready product.Additional preclinical testing is needed before human trials, but the researchers predict that  this approach could transform how the world responds to