Epigénétique Et Mémoire Cellulaire

Edith HeardCollège de FranceEpigénétique et mémoire cellulaireAnnée 2024-2025Conférence - Stephen Quake : Understanding the Mysteries of the Cell: Our Immune Repertoire Viewed Through the Darwin's EyesStephen QuakeHead of Science at the Chan Zuckerberg Initiative and Lee Otterson Professor at Stanford UniversityStephen Quake est invité par l'assemblée du Collège de France sur proposition de la Pr Edith Heard.RésuméThe nature of the immune system's antibody repertoire has been a subject of fascination for more than a century. This repertoire is highly plastic and can be directed to create antibodies with broad chemical diversity and high selectivity. There is now a good understanding of the potential diversity available and the mechanistic aspects of how this diversity is generated. Antibodies are formed by a mixture of recombination among gene segments, sequence diversification at the junctions of these segments, and point mutations throughout the gene. However, certain very elementary questions have remained