Kessler Foundation Disability Rehabilitation Research And Employment

Read the transcript at https://kesslerfoundation.org/sites/default/files/2025-06/Real%20Talk%20on%20MS%20Fatigue_What%20Works-What%E2%80%99s%20Next-TRANSCRIPT.pdf In this episode of Real Talk MS, host John Strum sits down with John DeLuca, PhD, senior vice president of Research and Training at Kessler Foundation, to explore the elusive nature of MS-related fatigue. Dr. DeLuca explains how fatigue is influenced by a complex mix of neurological and psychological factors, making it difficult to define and treat. He shares insights from MRI studies that link fatigue to changes in brain function—particularly in the basal ganglia—and highlights cognitive behavioral therapy as a leading treatment option, while also pointing to promising pharmacological developments on the horizon. The conversation expands to include Brian Sandroff, PhD, assistant director of the Center for Neuropsychology and Neuroscience Research at Kessler Foundation, who joins Dr. DeLuca in emphasizing the power of personalized, joyful activiti