Oncologie Cellulaire Et Moléculaire

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-202604 - Stress oxydant et thérapeutiques anti-tumorales : Le cas de la ferroptose

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-202603 - Stress oxydant et thérapeutiques anti-tumorales : Stress oxydant et radiothérapie

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-2026Hematopoietic Stem Cell Aging and Adaptation to StressConférence - Emmanuelle Passegué : Adaptive and Maladaptive Myeloid Cell ProductionEmmanuelle PasseguéDirectrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université ColumbiaRésuméAlthough young adult HSCs employ finely tuned mechanisms to balance pro-survival and stress responses, these maintenance strategies provoke vulnerabilities that manifest with continued age, leading to a decline in function. We will examine HSC biology through the lens of antagonistic pleiotropy, whereby the same mechanisms that are important for reproductive fitness form the basis for functional decline during aging. We will particularly highlight the central role of cell cycle regulation, niche cell reliance, inflammatory responses, cellular memory, and distinct metabolic regulation in driving HSC aging features, including expansion of the HSC poo

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-2026Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal DemandsConférence - Emmanuelle Passegué : Adaptive and Maladaptive Myeloid Cell ProductionEmmanuelle PasseguéDirectrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université ColumbiaRésuméAlthough highly regulated to maintain stable output of blood cells in health, the hematopoietic system is capable of extensive remodeling in response to external challenges, prioritizing production of certain blood cell types at the expense of others. We will consider how acute insults, such as infections and myeloablation, cause molecular, cellular, and metabolic changes in hematopoietic stem and progenitor cells at multiple levels of the hematopoietic hierarchy to drive accelerated production of mature myeloid cells needed to resolve the initiating insult. Moreover, we will discuss how dysregulation or subversion

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-2026Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal DemandsConférence - Emmanuelle Passegué : Environmental Crosstalk and Bone Marrow Niche RegulationEmmanuelle PasseguéDirectrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université ColumbiaRésuméIn adult mammals, HSCs reside in the bone marrow (BM) cavity near diverse groups of stromal cells, which maintain the structural integrity of both bone and marrow microenvironments. Interactions among stromal cells and hematopoietic stem and progenitor cells modulate many of the critical functions of the hematopoietic system, including production of specific blood lineages and responses to infection and inflammation. Our understanding of these interactions has grown considerably with application of new technologies that have uncovered how cell populations associate in situ and exchange molecular signals. We

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-202602 - Stress oxydant et thérapeutiques anti-tumorales : Stress oxydant et chimiothérapie

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-2026Hematopoietic Stem Cell through the Ages: A Lifetime of Adaptation to Organismal DemandsConférence - Emmanuelle Passegué : Principle of Hematopoietic Stem Cell Biology and Blood ProductionEmmanuelle PasseguéDirectrice de la Columbia Stem Cell Initiative et professeure émérite de génétique et de développement à l'université ColumbiaRésuméUnlike most adult organs, the blood system regenerates continuously to maintain homeostasis in a life-long process orchestrated by a complex collection of hematopoietic stem and progenitor cells. Self-renewing HSCs reside at the apex of this hierarchy and produce all blood lineages, including the erythroid lineage that forms red blood cells, the megakaryocytic lineage that gives rise to platelets, and the myeloid and lymphoid lineages that generate cells of the innate and adaptive immune systems. Most HSCs exist in a quiescent state, dividing occasionally to self-renew and produce various lineage-b

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2025-202601 - Stress oxydant et thérapeutiques anti-tumorales : principes généraux

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2024-2025Colloque - Oxidative Stress in Cancer - Raphaël Rodriguez : Chemical Control of Cell Adaptation in Cancer and ImmunityRaphaël RodriguezInstitut Curie, CNRS, INSERM

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2024-2025Colloque - Oxidative Stress in Cancer - Marcus Conrad : Ferroptosis Modulation for Disease PreventionMarcus ConradHelmholtz Zentrum München, Institute of Metabolism and Cell Death Neuherberg, Germany, Translational Redox Biology, Technical University of Munich (TUM), TUM Natural School of Sciences Garching, Germany

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2024-2025Colloque - Oxidative Stress in Cancer - Raphaël Itzykson : Targeting Cystine Import in Acute Myeloid LeukemiasRaphaël ItzyksonUniversité Paris Cité, Assistance Publique – Hôpitaux de Paris

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2024-202503 - Stress oxydant et cancers

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2024-202502 - Stress oxydant et cancers

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2024-202501 - Stress oxydant et cancers

Hugues de ThéCollège de FranceOncologie cellulaire et moléculaireAnnée 2023-2024Exploring the World of Protein Post-translational ModificationsConférence - Tony Hunter : New Insights into Intercellular Crosstalk between Different Cell Populations in Pancreatic Tumors That Can Be Translated into the ClinicTony HunterSalk Institute, La Jolla, California, USARésuméPancreatic adenocarcinoma (PDA) is one of the most lethal cancers, primarily due to late diagnosis. PDA is a highly stromal (desmoplastic) and poorly vascularized tumor with a dense extracellular matrix; only ~10% of the cells in the tumor are tumor cells, with the rest of the tumor microenvironment (TME) being comprised of cancer-associated fibroblasts (CAFs, and immune cells, including tumor-associated macrophages (TAMs). To investigate the role of cellular crosstalk between CAFs and tumor cells TME, we set out to identify paracrine factors secreted by activated CAFs in the tumor tissue that act on the tumor cells and can be targeted for therapeutic

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : Cellular Responses to DNA Damage: From Stalled Forks to Inflammation and BeyondIntervenant(s)Philippe PaseroInstitut de Génétique Humaine, CNRS et université de Montpellier

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : GENerating a Break in the Proliferation of Cells after Whole Genome DuplicationIntervenant(s)Renata BastoInstitut Curie et CNRS

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : Studying Melanoma Evolution One Cell at the TimeIntervenant(s)Chris MarineVIB – Leuven Belgique

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : Targeting the DNA Damage Response and Immune Response Interplay: Novel Therapeutic OpportunitiesIntervenant(s)Sophie Postel-VinayInstitut Gustave Roussy et University College of London

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Explorer la réponse thérapeutique in vivo : How Homologous Recombination (HR)-Deficient Tumors Survive Genomic InstabilityIntervenant(s)Raphaël CeccaldiInstitut Curie/INSERM