In Our Time

Melvyn Bragg and guests discuss penicillin, discovered by Alexander Fleming in 1928. It is said he noticed some blue-green penicillium mould on an uncovered petri dish at his hospital laboratory, and that this mould had inhibited bacterial growth around it. After further work, Fleming filtered a broth of the mould and called that penicillin, hoping it would be useful as a disinfectant. Howard Florey and Ernst Chain later shared a Nobel Prize in Medicine with Fleming, for their role in developing a way of mass-producing the life-saving drug. Evolutionary theory predicted the risk of resistance from the start and, almost from the beginning of this 'golden age' of antibacterials, scientists have been looking for ways to extend the lifespan of antibiotics.WithLaura Piddock Professor of Microbiology at the University of BirminghamChristoph Tang Professor of Cellular Pathology and Professorial Fellow at Exeter College at the University of OxfordAndSteve Jones Emeritus Professor of Genetics at University College, Lo

Melvyn Bragg and guests discuss the English mystic Margery Kempe (1373-1438) whose extraordinary life is recorded in a book she dictated, The Book of Margery Kempe. She went on pilgrimage to Jerusalem, to Rome and Santiago de Compostela, purchasing indulgences on her way, met with the anchoress Julian of Norwich and is honoured by the Church of England each 9th November. She sometimes doubted the authenticity of her mystical conversations with God, as did the authorities who saw her devotional sobbing, wailing and convulsions as a sign of insanity and dissoluteness. Her Book was lost for centuries, before emerging in a private library in 1934.The image (above), of an unknown woman, comes from a pew at Margery Kempe's parish church, St Margaret's, Kings Lynn and dates from c1375.WithMiri Rubin Professor of Medieval and Early Modern History at Queen Mary, University of LondonKatherine Lewis Senior Lecturer in History at the University of HuddersfieldAndAnthony Bale Professor of Medieval Studies at Birkbeck Univ

Melvyn Bragg and guests discuss Abraham Lincoln's Gettysburg Address, ten sentences long, delivered at the dedication of the Soldiers' National Cemetery at Gettysburg after the Union forces had won an important battle with the Confederates. Opening with " Four score and seven years ago," it became one of the most influential statements of national purpose, asserting that America was "conceived in liberty, and dedicated to the proposition that all men are created equal" and "that this nation, under God, shall have a new birth of freedom-and that government of the people, by the people, for the people, shall not perish from the earth." Among those inspired were Martin Luther King Jr whose "I have a dream" speech, delivered at the Lincoln Memorial 100 years later, echoed Lincoln's opening words.With Catherine Clinton Denman Chair of American History at the University of Texas and International Professor at Queen's University, BelfastSusan-Mary Grant Professor of American History at Newcastle UniversityAndTim Loc

Melvyn Bragg and guests discuss the Muses and their role in Greek mythology, when they were goddesses of poetry, song, music and dance: what the Greeks called mousike, 'the art of the Muses' from which we derive our word 'music.' While the number of Muses, their origin and their roles varied in different accounts and at different times, they were consistently linked with the nature of artistic inspiration. This raised a question for philosophers then and since: was a creative person an empty vessel into which the Muses poured their gifts, at their will, or could that person do something to make inspiration flow? WithPaul Cartledge Emeritus Professor of Greek Culture and AG Leventis Senior Research Fellow at Clare College, University of CambridgeAngie Hobbs Professor of the Public Understanding of Philosophy, University of SheffieldAndPenelope Murray Founder member and retired Senior Lecturer, Department of Classics, University of WarwickProducer: Simon TillotsonImage: 'Apollo and the Muses (Parnassus)', 1631-

Melvyn Bragg and guests discuss Titus Oates (1649-1705) who, with Israel Tonge, spread rumours of a Catholic plot to assassinate Charles II. From 1678, they went to great lengths to support their scheme, forging evidence and identifying the supposed conspirators. Fearing a second Gunpowder Plot, Oates' supposed revelations caused uproar in London and across the British Isles, with many Catholics, particularly Jesuit priests, wrongly implicated by Oates and then executed. Anyone who doubted him had to keep quiet, to avoid being suspected a sympathiser and thrown in prison. Oates was eventually exposed, put on trial under James II and sentenced by Judge Jeffreys to public whipping through the streets of London, but the question remained: why was this rogue, who had faced perjury charges before, ever believed?WithClare Jackson Senior Tutor and Director of Studies in History at Trinity Hall, University of CambridgeMark Knights Professor of History at the University of WarwickAndPeter Hinds Associate Professor of

Melvyn Bragg and guests discuss Tess of the d'Urbervilles by Thomas Hardy, originally serialised in The Graphic in 1891 and, with some significant changes, published as a complete novel in 1892. The book was controversial even before serialisation, rejected by one publisher as too overtly sexual, to which a second added it did not publish 'stories where the plot involves frequent and detailed reference to immoral situations.' Hardy's description of Tess as 'A Pure Woman' in 1892 incensed some Victorian readers. He resented having to censor some of his scenes in the early versions, including references to Tess's baby following her rape by Alec d'Urberville, and even to a scene where Angel Clare lifted four milkmaids over a flooded lane (substituting transportation by wheelbarrow).The image above, from the 1891 edition, is captioned 'It Was Not Till About Three O'clock That Tess Raised Her Eyes And Gave A Momentary Glance Round. She Felt But Little Surprise At Seeing That Alec D'urberville Had Come Back, And Wa

Melvyn Bragg and guests discuss Euclid's Elements, a mathematical text book attributed to Euclid and in use from its appearance in Alexandria, Egypt around 300 BC until modern times, dealing with geometry and number theory. It has been described as the most influential text book ever written. Einstein had a copy as a child, which he treasured, later saying "If Euclid failed to kindle your youthful enthusiasm, then you were not born to be a scientific thinker."With Marcus du Sautoy Professor of Mathematics and Simonyi Professor for the Public Understanding of Science at the University of OxfordSerafina Cuomo Reader in Roman History at Birkbeck University of LondonAnd June Barrow-Green Professor of the History of Mathematics at the Open UniversityProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the impact of the eruption of Mt Tambora, in 1815, on the Indonesian island of Sambawa. This was the largest volcanic eruption in recorded history and it had the highest death toll, devastating people living in the immediate area. Tambora has been linked with drastic weather changes in North America and Europe the following year, with frosts in June and heavy rains throughout the summer in many areas. This led to food shortages, which may have prompted westward migration in America and, in a Europe barely recovered from the Napoleonic Wars, led to widespread famine. With Clive Oppenheimer Professor of Volcanology at the University of CambridgeJane Stabler Professor in Romantic Literature at the University of St AndrewsAndLawrence Goldman Director of the Institute of Historical Research at the University of LondonProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the neutron, one of the particles found in an atom's nucleus. Building on the work of Ernest Rutherford, the British physicist James Chadwick won the Nobel Prize for Physics for his discovery of the neutron in 1932. Neutrons play a fundamental role in the universe and their discovery was at the heart of developments in nuclear physics in the first half of the 20th century. With Val Gibson Professor of High Energy Physics at the University of Cambridge and fellow of Trinity CollegeAndrew Harrison Chief Executive Officer of Diamond Light Source and Professor in Chemistry at the University of EdinburghAndFrank Close Professor Emeritus of Physics at the University of Oxford.

Melvyn Bragg and guests discuss the rise of the Sikh Empire at the end of the 18th Century under Ranjit Singh, pictured above, who unified most of the Sikh kingdoms following the decline of the Mughal Empire. He became Maharaja of the Punjab at Lahore in 1801, capturing Amritsar the following year. His empire flourished until 1839, after which a decade of unrest ended with the British annexation. At its peak, the Empire covered the Punjab and stretched from the Khyber Pass in the west to the edge of Tibet in the east, up to Kashmir and down to Mithankot on the Indus River. Ranjit Singh is still remembered as "The Lion of the Punjab."With Gurharpal Singh Professor in Inter-Religious Relations and Development at SOAS, University of LondonChandrika Kaul Lecturer in Modern History at the University of St AndrewsAndSusan Stronge Senior Curator in the Asian Department of the Victoria and Albert MuseumProducer: Simon Tillotson.

Agrippina the Younger was one of the most notorious and influential of the Roman empresses in the 1st century AD. She was the sister of the Emperor Caligula, a wife of the Emperor Claudius and mother of the Emperor Nero. Through careful political manoeuvres, she acquired a dominant position for herself in Rome. In 39 AD she was exiled for allegedly participating in a plot against Caligula and later it was widely thought that she killed Claudius with poison. When Nero came to the throne, he was only 16 so Agrippina took on the role of regent until he began to exert his authority. After relations between Agrippina and Nero soured, he had her murdered.With:Catharine Edwards Professor of Classics and Ancient History at Birkbeck, University of LondonAlice König Lecturer in Latin and Classical Studies at the University of St AndrewsMatthew Nicholls Associate Professor of Classics at the University of ReadingProducer: Victoria Brignell.

Melvyn Bragg and guests discuss Elizabeth Barrett Browning's epic "Aurora Leigh" which was published in 1856. It is the story of an orphan, Aurora, born in Italy to an English father and Tuscan mother, who is brought up by an aunt in rural Shropshire. She has a successful career as a poet in London and, when living in Florence, is reunited with her cousin, Romney Leigh, whose proposal she turned down a decade before. The poem was celebrated by other poets and was Elizabeth Barrett Browning's most commercially successful. Over 11,000 lines, she addressed many Victorian social issues, including reform, illegitimacy, the pressure to marry and what women must overcome to be independent, successful writers, in a world dominated by men. With Margaret Reynolds Professor of English at Queen Mary, University of LondonDaniel Karlin Winterstoke Professor of English Literature at the University of BristolAndKaren O'Brien Professor of English Literature at King's College LondonProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the early years of Bedlam, the name commonly used for the London hospital of St Mary of Bethlehem outside Bishopsgate, described in 1450 by the Lord Mayor of London as a place where may "be found many men that be fallen out of their wit. And full honestly they be kept in that place; and some be restored onto their wit and health again. And some be abiding therein for ever." As Bethlem, or Bedlam, it became a tourist attraction in the 17th Century at its new site in Moorfields and, for its relatively small size, made a significant impression on public attitudes to mental illness. The illustration, above, is from the eighth and final part of Hogarth's 'A Rake's Progress' (1732-3), where Bedlam is the last stage in the decline and fall of a young spendthrift,Tom Rakewell.With Hilary Marland Professor of History at the University of WarwickJustin Champion Professor of the History of Early Modern Ideas at Royal Holloway, University of London and President of the Historical Associati

Melvyn Bragg and guests discuss the Maya Civilization, developed by the Maya people, which flourished in central America from around 250 AD in great cities such as Chichen Itza and Uxmal with advances in mathematics, architecture and astronomy. Long before the Spanish Conquest in the 16th Century, major cities had been abandoned for reasons unknown, although there are many theories including overpopulation and changing climate. The hundreds of Maya sites across Belize, El Salvador, Guatemala, Honduras and Mexico raise intriguing questions about one of the world's great pre-industrial civilizations.WithElizabeth Graham Professor of Mesoamerican Archaeology at University College LondonMatthew Restall Edwin Erle Sparks Professor of Latin American History and Anthropology at Pennsylvania State UniversityAndBenjamin Vis Eastern ARC Research Fellow in Digital Humanities at the University of KentProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the Vereenigde Oost-Indische Compagnie or VOC, known in English as the Dutch East India Company. The VOC dominated the spice trade between Asia and Europe for two hundred years, with the British East India Company a distant second. At its peak, the VOC had a virtual monopoly on nutmeg, mace, cloves and cinnamon, displacing the Portuguese and excluding the British, and were the only European traders allowed access to Japan.With Anne Goldgar Reader in Early Modern European History at King's College LondonChris Nierstrasz Lecturer in Global History at Erasmus University, Rotterdam, formerly at the University of WarwickAndHelen Paul Lecturer in Economics and Economic History at the University of SouthamptonProducer: Simon Tillotson.

Mary Magdalene is one of the best-known figures in the Bible and has been a frequent inspiration to artists and writers over the last 2000 years. According to the New Testament, she was at the foot of the cross when Jesus was crucified and was one of the first people to see Jesus after the resurrection. However, her identity has provoked a large amount of debate and in the Western Church she soon became conflated with two other figures mentioned in the Bible, a repentant sinner and Mary of Bethany. Texts discovered in the mid-20th century provoked controversy and raised further questions about the nature of her relations with Jesus.With:Joanne Anderson Lecturer in Art History at the Warburg Institute, School of Advanced Study, University of LondonEamon Duffy Emeritus Professor of the History of Christianity at the University of Cambridge and Fellow of Magdalene CollegeJoan Taylor Professor of Christian Origins and Second Temple Judaism at King's College LondonProducer: Victoria Brignell.

Melvyn Bragg and guests discuss the life and work of Robert Hooke (1635-1703) who worked for Robert Boyle and was curator of experiments at the Royal Society. The engraving of a flea, above, is taken from his Micrographia which caused a sensation when published in 1665. Sometimes remembered for his disputes with Newton, he studied the planets with telescopes and snowflakes with microscopes. He was an early proposer of a theory of evolution, discovered light diffraction with a wave theory to explain it and felt he was rarely given due credit for his discoveries. WithDavid Wootton Anniversary Professor of History at the University of YorkPatricia Fara President Elect of the British Society for the History of ScienceAndRob Iliffe Professor of History of Science at Oxford UniversityProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the poetry of Rumi, the Persian scholar and Sufi mystic of the 13th Century. His great poetic works are the Masnavi or "spiritual couplets" and the Divan, a collection of thousands of lyric poems. He is closely connected with four modern countries: Afghanistan, as he was born in Balkh, from which he gains the name Balkhi; Uzbekistan from his time in Samarkand as a child; Iran as he wrote in Persian; and Turkey for his work in Konya, where he spent most of his working life and where his followers established the Mevlevi Order, also known as the Whirling Dervishes.With Alan Williams British Academy Wolfson Research Professor at the University of ManchesterCarole Hillenbrand Professor of Islamic History at the University of St Andrews and Professor Emerita of Edinburgh UniversityAnd Lloyd Ridgeon Reader in Islamic Studies at the University of GlasgowProducer: Simon Tillotson.

Melvyn Bragg and guests discuss the origins, development and uses of chromatography. In its basic form, it is familiar to generations of schoolchildren who put a spot of ink at the bottom of a strip of paper, dip it in water and then watch the pigments spread upwards, revealing their separate colours. Chemists in the 19th Century started to find new ways to separate mixtures and their work was taken further by Mikhail Tsvet, a Russian-Italian scientist who is often credited with inventing chromatography in 1900. The technique has become so widely used, it is now an integral part of testing the quality of air and water, the levels of drugs in athletes, in forensics and in the preparation of pharmaceuticals.WithAndrea Sella Professor of Chemistry at University College LondonApryll Stalcup Professor of Chemical Sciences at Dublin City UniversityAndLeon Barron Senior Lecturer in Forensic Science at King's College London.

Melvyn Bragg and guests discuss the life, times and influence of Eleanor of Aquitaine (c1122-1204) who was one of the most powerful women in Twelfth Century Europe, possibly in the entire Middle Ages. She inherited land from the Loire down to the Pyrenees, about a third of modern France. She married first the King of France, Louis VII, joining him on the Second Crusade. She became stronger still after their marriage was annulled, as her next husband, Henry Plantagenet became Henry II of England. Two of their sons, Richard and John, became kings and she ruled for them when they were abroad. By her death in her eighties, Eleanor had children and grandchildren in power across western Europe. This led to competing claims of inheritance and, for much of the next 250 years, the Plantagenet and French kings battled over Eleanor's land.WithLindy Grant Professor of Medieval History at the University of ReadingNicholas Vincent Professor of Medieval History at the University of East AngliaAndJulie Barrau University Lect